Reds vs. Pirates Prediction: Cincinnati Predicted to Win Wednesday's MLB Matchup [5/21/2025]

MLB action continues on Wednesday at 12:35PM ET as the Cincinnati Reds lock horns with the Pittsburgh Pirates at PNC Park.

Andrew Heaney (2-3, 3.02 ERA) will get the ball for the Pirates, while the Reds have opted for Brady Singer (5-2, 5.01 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Reds as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cincinnati-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Reds' chance of winning at 51%, with the Pirates at 49%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Reds vs. Pirates predictions page.

Pirates vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Reds and Pirates 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Reds a 51% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 63% chance of covering the run line, while the over/under total of 8 runs has a 52% chance of staying under.

Reds vs. Pirates Odds [5/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Pirates
Run Line	-1.5 (+140)	+1.5 (-156)
Moneyline	-125	+110
Total	o8 (-102)	u8 (-105)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Pirates Picks and Best Bets

Our model's strongest edge in today's Reds vs. Pirates matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

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Reds vs. Pirates Game-Day Updates and Essential Details

Wednesday's MLB game between the Pirates and Reds at PNC Park is scheduled to commence at 12:35PM ET.

• Who: Cincinnati Reds vs. Pittsburgh Pirates
• Date: Wednesday, May 21, 2025
• Time: 12:35PM ET/9:35AM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Wednesday's Reds vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Cincinnati vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Reds, with a 51% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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