Reds vs. Pirates Prediction: Pittsburgh Predicted to Win Monday's MLB Matchup [5/19/2025]

The Pittsburgh Pirates and Cincinnati Reds are scheduled to meet in MLB action at PNC Park on Monday, starting at 6:40PM ET.

The Pirates will have Mitch Keller (1-5, 4.15 ERA) as their starting pitcher, while the Reds are going with Nick Lodolo (3-4, 3.42 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Pirates as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Cincinnati-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Pirates are likely to win, with a probability of 51%, compared to the Reds' 49%."

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Reds vs. Pirates predictions page.

Pirates vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Monday's MLB matchup between the Reds and Pirates 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Pirates a 51% chance of beating the Reds.

According to our model, the Pirates (+1.5) have a 63% chance of covering the run line, while the over/under total of 8.5 runs has a 56% chance of staying under.

Reds vs. Pirates Odds [5/19/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Pirates
Run Line	-1.5 (+145)	+1.5 (-170)
Moneyline	-116	-102
Total	o8.5 (-102)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Pirates Picks and Best Bets

Our model's strongest edge in today's Reds vs. Pirates matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Reds vs. Pirates Game-Day Updates and Essential Details

Monday's MLB matchup between the Pirates and Reds at PNC Park is scheduled to begin at 6:40PM ET.

• Who: Cincinnati Reds vs. Pittsburgh Pirates
• Date: Monday, May 19, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Monday's Reds vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Cincinnati vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Pirates, with a 51% win probability, will likely beat the Reds on Monday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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