Reds vs. Brewers prediction: Why Milwaukee is favored to win Saturday's MLB matchup [9/27/2025]

MLB action continues on Saturday at 7:15PM ET as the Cincinnati Reds lock horns with the Milwaukee Brewers at American Family Field.

The Brewers will start Robert Gasser (0-1, 6.00 ERA), while the Reds have opted for Andrew Abbott (9-7, 2.80 ERA).

Based on updated simulation results, Dimers' proven MLB model projects the Brewers as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Reds vs. Brewers predictions page.

Brewers vs. Reds prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the result of Saturday's MLB matchup between the Reds and Brewers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Brewers a 55% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 63% chance of covering the run line, while the over/under total of 8 runs has a 58% chance of going over.

Reds vs. Brewers odds [9/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Brewers
Run Line	+1.5 (-200)	-1.5 (+167)
Moneyline	+108	-125
Total	o8 (-110)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Brewers picks and best bets

Our model's strongest edge in today's Reds vs. Brewers matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Reds vs. Brewers game-day updates and essential details

Saturday's MLB game between the Brewers and Reds at American Family Field is scheduled to commence at 7:15PM ET.

• Who: Cincinnati Reds vs. Milwaukee Brewers
• Date: Saturday, September 27, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: American Family Field

Dimers' full preview of Saturday's Reds vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Brewers, with a 55% win probability, will likely beat the Reds on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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