Reds vs. Brewers prediction: Why Milwaukee is favored to win Friday's MLB matchup [9/26/2025]

The Milwaukee Brewers will square off with the Cincinnati Reds in MLB action at American Family Field on Friday, starting at 8:10PM ET.

The Brewers will send Quinn Priester (13-2, 3.25 ERA) to the mound, up against Zack Littell (10-8, 3.86 ERA) for the Reds.

Based on updated simulation results, Dimers' advanced MLB model predicts the Brewers as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Reds vs. Brewers predictions page.

Brewers vs. Reds prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the Reds and Brewers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Brewers a 60% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 58% chance of covering the run line, while the 8-run over/under has a 58% chance of going over.

Reds vs. Brewers odds [9/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Brewers
Run Line	+1.5 (-150)	-1.5 (+135)
Moneyline	+144	-165
Total	o8 (-105)	u8 (-115)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Brewers picks and best bets

Our model's strongest edge in today's Reds vs. Brewers matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Reds vs. Brewers game-day updates and essential details

Friday's MLB game between the Brewers and Reds at American Family Field is scheduled to start at 8:10PM ET.

• Who: Cincinnati Reds vs. Milwaukee Brewers
• Date: Friday, September 26, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: American Family Field

Dimers' full preview of Friday's Reds vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Brewers, with a 60% win probability, will likely beat the Reds on Friday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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