Reds vs. Cubs Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [8/6/2025]

MLB action continues on Wednesday at 2:20PM ET as the Cincinnati Reds lock horns with the Chicago Cubs at Wrigley Field.

The Cubs will have Cade Horton (5-3, 3.42 ERA) as their starting pitcher, while the Reds have opted for Andrew Abbott (8-1, 2.15 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game. "Our team has simulated the outcome of Wednesday's Reds-Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 56%, with the Reds at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Reds vs. Cubs predictions page.

Cubs vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Reds and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 56% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 63% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.

Reds vs. Cubs Odds [8/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Cubs
Run Line	+1.5 (-200)	-1.5 (+165)
Moneyline	+110	-130
Total	o7.5 (+102)	u7.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Reds vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Reds vs. Cubs Game-Day Updates and Essential Details

Wednesday's MLB action between the Cubs and Reds at Wrigley Field is scheduled to begin at 2:20PM ET.

• Who: Cincinnati Reds vs. Chicago Cubs
• Date: Wednesday, August 6, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Wednesday's Reds vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 56% win probability, will likely beat the Reds on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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