Reds vs. Cubs Prediction: Cubs Predicted to Win Tuesday's MLB Matchup [8/5/2025]

MLB action continues on Tuesday at 8:05PM ET as the Cincinnati Reds take on the Chicago Cubs at Wrigley Field.

The Cubs will start Shota Imanaga (8-4, 3.25 ERA), while the Reds have opted for Zack Littell (8-8, 3.58 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Reds vs. Cubs predictions page.

Cubs vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Tuesday's MLB game between the Reds and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 62% chance of defeating the Reds.

According to our model, the Reds (+1.5) have a 57% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.

Reds vs. Cubs Odds [8/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Cubs
Run Line	+1.5 (-140)	-1.5 (+118)
Moneyline	+155	-181
Total	o7.5 (+100)	u7.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Reds vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Reds vs. Cubs Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Cubs and Reds at Wrigley Field is scheduled to begin at 8:05PM ET.

• Who: Cincinnati Reds vs. Chicago Cubs
• Date: Tuesday, August 5, 2025
• Time: 8:05PM ET/5:05PM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Tuesday's Reds vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 62% win probability, will likely beat the Reds on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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