Reds vs. Cubs Prediction: Cubs Predicted to Win Saturday's MLB Matchup [5/31/2025]

The Chicago Cubs will take on the Cincinnati Reds in MLB action at Wrigley Field on Saturday, commencing at 2:20PM ET.

The Cubs will start Drew Pomeranz (2-0, 0.00 ERA), while the Reds have opted for Nick Lodolo (4-4, 3.39 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Cincinnati-CHI Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Cubs are more likely to win, while the Reds have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Reds vs. Cubs predictions page.

Cubs vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Saturday's MLB game between the Reds and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 61% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 59% chance of covering the run line, while the over/under total of 7.5 runs has a 53% chance of staying under.

Reds vs. Cubs Odds [5/31/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Cubs
Run Line	+1.5 (-160)	-1.5 (+135)
Moneyline	+145	-166
Total	o7.5 (+105)	u7.5 (-135)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Reds vs. Cubs matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Reds vs. Cubs Game-Day Updates and Essential Details

Saturday's MLB action between the Cubs and Reds at Wrigley Field is scheduled to begin at 2:20PM ET.

• Who: Cincinnati Reds vs. Chicago Cubs
• Date: Saturday, May 31, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's full preview of Saturday's Reds vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Cincinnati vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 61% win probability, will likely beat the Reds on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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