Reds vs. Diamondbacks prediction: Why Arizona is favored to win Friday's MLB matchup [8/22/2025]

The Arizona Diamondbacks will take on the Cincinnati Reds in MLB action at Chase Field on Friday, starting at 9:40PM ET.

Ryne Nelson (6-3, 3.58 ERA) will be on the bump for the Diamondbacks, while the Reds are going with Zack Littell (9-8, 3.52 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts the Diamondbacks as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Reds vs. Diamondbacks predictions page.

Diamondbacks vs. Reds prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the outcome of Friday's MLB game between the Reds and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Diamondbacks a 56% chance of defeating the Reds.

According to our model, the Reds (+1.5) have a 62% chance of covering the run line, while the over/under total of 9 runs has a 51% chance of going over.

Reds vs. Diamondbacks odds [8/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Diamondbacks
Run Line	+1.5 (-184)	-1.5 (+155)
Moneyline	+114	-130
Total	o9 (-104)	u9 (-112)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Reds vs. Diamondbacks matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Reds vs. Diamondbacks game-day updates and essential details

Friday's MLB action between the Diamondbacks and Reds at Chase Field is scheduled to commence at 9:40PM ET.

• Who: Cincinnati Reds vs. Arizona Diamondbacks
• Date: Friday, August 22, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's in-depth preview of Friday's Reds vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Diamondbacks, with a 56% win probability, will likely beat the Reds on Friday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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