Cincinnati Bengals vs. Denver Broncos early prediction: Expert picks for NFL Week 4, 2025

The Cincinnati Bengals and Denver Broncos will meet in Week 4 of the NFL season at Empower Field at Mile High on Monday, September 29, 2025, starting at 8:15PM ET.

Early simulations from Dimers' trusted NFL model favor the Broncos as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bengals vs. Broncos predictions page.

Cincinnati vs. Denver early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bengals vs. Broncos game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bengals 39%, Broncos 61%
• Predicted final score: Bengals 22-25 Broncos
• Spread: Bengals (+2.5) 42%, Broncos (-2.5) 58%
• Total points (47.5): Over 50%, Under 50%

As of September 21, 2025, these Bengals-Broncos numbers and predictions reflect the latest data and insights available.

Bengals vs. Broncos Week 4 details

The NFL Week 4 game between the Broncos and Bengals at Empower Field at Mile High is scheduled for September 29, 2025.

• Who: Cincinnati Bengals vs. Denver Broncos
• Date: Monday, September 29, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Empower Field at Mile High

Bengals vs. Broncos opening odds

We've researched the best betting odds across America for this Week 4 game, which are listed here:

• Spread: Bengals +2.5 (-110), Broncos -2.5 (-110)
• Moneyline: Bengals +114, Broncos -135
• Total: Over/Under 47.5 (-112/-108)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Broncos, with a 61% win probability, will likely beat the Bengals in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bengals vs. Broncos game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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