Chiefs vs. Cardinals Week 1 Prediction and Odds - Sep 11, 2022

The Arizona Cardinals and Kansas City Chiefs clash in Week 1 of the NFL season at State Farm Stadium on Sunday, starting at 4:25PM ET.

Dimers' free betting picks for Chiefs vs. Cardinals, plus game predictions, betting odds and touchdown scorer probabilities, are detailed below.

Today's Kansas City vs. Arizona betting preview is proudly sponsored by FanDuel Sportsbook, which has a tasty Bet $5, Get $150 promo for new users.

Who will win Chiefs vs. Cardinals?

Using advanced machine learning and data, Dimers.com has simulated Sunday's Chiefs-Cardinals NFL matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, currently gives the Chiefs a 69% chance of beating the Cardinals in Week 1 of the NFL season.

More: Chiefs vs. Cardinals Simulated 10K Times

Chiefs vs. Cardinals Week 1 Odds

• Spread: Cardinals +6 (-105), Chiefs -6 (-107)
• Moneyline: Cardinals +230, Chiefs -240
• Total: Over/Under 54 (-107/-107)

Point Spread, Moneyline and Over/Under

The Cardinals are +6 underdogs versus the Chiefs, with -105 at DraftKings Sportsbook the best odds currently available.

For the favored Chiefs (-6) to cover the spread, PointsBet has the best odds currently on offer at -107.

FanDuel Sportsbook currently has the best moneyline odds for the Cardinals at +230, which means you can bet $100 to profit $230, earning a total payout of $330, if they win.

Meanwhile, PointsBet currently has the best moneyline odds for the Chiefs at -240, where you can risk $240 to win $100, for a total payout of $340, if they come out on top.

The Over/Under for total points scored is set at 54 with PointsBet, which currently has the best odds for the Over at -107, as well as the best odds for the Under at -107.

As always, check out the sportsbooks you can bet with in your state for the best NFL odds and lines.

According to DimersBOT, the Chiefs (-6) are a 54% chance of covering the spread, while the Over/Under total of 54 points is a 53% chance of going Under.

More: Track Your Bets via Bet Center

Best Bets for Chiefs vs. Cardinals

• Spread: Chiefs -6 @ -107 via PointsBet (54% probability)
• Moneyline: Cardinals @ +230 via FanDuel Sportsbook (0.2% edge)
• Total: Under 54 @ -107 via PointsBet (53% probability)

Dimers' best bets are based on world-class modeling and betting intelligence to serve you the best possible plays 24/7/365.

While the Chiefs are more likely to win the game, according to DimersBOT, taking the Cardinals moneyline is the best option due to the edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers.com is one of the keys to being profitable in the long run.

Chiefs vs. Cardinals Prediction

Dimers.com's predicted final score for Kansas City vs. Arizona at State Farm Stadium in Week 1 has the Chiefs winning 29-23.

Click or tap on See Matchup for more.

Dimers has full coverage of this week's Chiefs-Cardinals matchup in Week 1, including pregame predictions, best betting picks, and live win probabilities.

Chiefs vs. Cardinals Player Props

Who will score an anytime touchdown in Chiefs vs. Cardinals? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the Chiefs and Cardinals, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you discover the best prop bets for Sunday's game.

According to DimersBOT, Arizona's James Conner is most likely to score the first touchdown in Chiefs vs. Cardinals.

DimersBOT gives Conner a 10.7% chance of getting in for six first at State Farm Stadium, while the Cardinals RB is a 50.6% chance of reaching the end zone at any point during the game.

Scroll down for the full list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

Kansas City Chiefs

• Travis Kelce: 10.1% probability
• Clyde Edwards-Helaire: 7.7% probability
• JuJu Smith-Schuster: 6.7% probability
• Mecole Hardman: 6.6% probability
• Marquez Valdes-Scantling: 6.5% probability

Arizona Cardinals

• James Conner: 10.7% probability
• Kyler Murray: 6.3% probability
• Marquise Brown: 6.1% probability
• Zach Ertz: 5.2% probability
• A.J. Green: 4.6% probability

Anytime Touchdown Scorer Probabilities

Kansas City Chiefs

• Travis Kelce: 48.3% probability
• Clyde Edwards-Helaire: 40.3% probability
• JuJu Smith-Schuster: 35.2% probability
• Marquez Valdes-Scantling: 34.4% probability
• Mecole Hardman: 34.3% probability

Arizona Cardinals

• James Conner: 50.6% probability
• Kyler Murray: 33.0% probability
• Marquise Brown: 32.7% probability
• Zach Ertz: 29.0% probability
• A.J. Green: 25.7% probability

Chiefs-Cardinals Projected Player Stats

Of the starting quarterbacks, the Chiefs' Patrick Mahomes is projected to have a big game with 307 passing yards. The Cardinals' Kyler Murray is expected to throw for 259 yards.

Chiefs Starting QB

• Patrick Mahomes: 307 projected yards

Cardinals Starting QB

• Kyler Murray: 259 projected yards

Chiefs Rushing

• Clyde Edwards-Helaire: 58 projected yards
• Patrick Mahomes: 21 projected yards
• Isiah Pacheco: 17 projected yards

Cardinals Rushing

• James Conner: 54 projected yards
• Kyler Murray: 34 projected yards
• Eno Benjamin: 13 projected yards

Chiefs Receiving

• Travis Kelce: 78 projected yards
• JuJu Smith-Schuster: 63 projected yards
• Marquez Valdes-Scantling: 54 projected yards
• Mecole Hardman: 44 projected yards
• Skyy Moore: 36 projected yards

Cardinals Receiving

• A.J. Green: 68 projected yards
• Marquise Brown: 52 projected yards
• Zach Ertz: 43 projected yards
• Greg Dortch: 29 projected yards
• James Conner: 24 projected yards

Remember, DimersBOT updates frequently, so refresh this article for the latest betting analysis before Chiefs vs. Cardinals on Sunday September 11, 2022.

Chiefs vs. Cardinals 2022

The NFL Week 1 matchup between the Cardinals and Chiefs at State Farm Stadium is scheduled to start at 4:25PM ET.

• Who: Kansas City Chiefs vs. Arizona Cardinals
• Date: Sunday September 11, 2022
• Time: 4:25PM ET / 1:25PM PT
• Venue: State Farm Stadium

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