White Sox vs. Nationals prediction: Why Washington is favored to win Friday's MLB matchup [9/26/2025]

The Washington Nationals and Chicago whitesox will lock horns in MLB action at Nationals Park on Friday, starting at 6:45PM ET.

Cade Cavalli (3-1, 4.23 ERA) will start for the Nationals, while the White Sox have opted for Yoendrys Gómez (3-3, 4.92 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts the Nationals as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive White Sox vs. Nationals predictions page.

Nationals vs. White Sox prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB game between the White Sox and Nationals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Nationals a 55% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 61% chance of covering the run line, while the 8.5-run over/under has a 57% chance of going over.

White Sox vs. Nationals odds [9/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Nationals
Run Line	+1.5 (-187)	-1.5 (+165)
Moneyline	+110	-130
Total	o8.5 (-120)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Nationals picks and best bets

Our model's biggest edge in today's White Sox vs. Nationals matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

White Sox vs. Nationals game-day updates and essential details

Friday's MLB game between the Nationals and White Sox at Nationals Park is scheduled to commence at 6:45PM ET.

• Who: Chicago White Sox vs. Washington Nationals
• Date: Friday, September 26, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Nationals Park

Dimers' comprehensive preview of Friday's White Sox vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Nationals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Nationals, with a 55% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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