White Sox vs. Pirates Prediction: Pittsburgh Predicted to Win Friday's MLB Matchup [7/18/2025]

The Pittsburgh Pirates will square off with the Chicago White Sox in MLB action at PNC Park on Friday, beginning at 6:40PM ET.

The Pirates will start Bailey Falter (6-4, 3.79 ERA), while the White Sox have opted for Jonathan Cannon (3-7, 4.44 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Pirates as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive White Sox vs. Pirates predictions page.

Pirates vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Friday's MLB matchup between the White Sox and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Pirates a 59% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 59% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of staying under.

White Sox vs. Pirates Odds [7/18/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Pirates
Run Line	+1.5 (-160)	-1.5 (+142)
Moneyline	+134	-155
Total	o8.5 (-110)	u8.5 (-106)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Pirates Picks and Best Bets

Our model's strongest edge in today's White Sox vs. Pirates matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

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White Sox vs. Pirates Game-Day Updates and Essential Details

Friday's MLB action between the Pirates and White Sox at PNC Park is scheduled to commence at 6:40PM ET.

• Who: Chicago White Sox vs. Pittsburgh Pirates
• Date: Friday, July 18, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Friday's White Sox vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Pirates picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Pirates, with a 59% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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