White Sox vs. Yankees prediction: Cy Young candidate Max Fried takes on White Sox tonight [9/24/2025]

The New York Yankees and Chicago whitesox will lock horns in MLB action at Yankee Stadium on Wednesday, starting at 7:05PM ET.

The Yankees will start Cy Young fancy Max Fried (18-5, 2.92 ERA), pitting him against Fraser Ellard (0-2, 4.50 ERA) for the White Sox.

Based on the latest simulations, Dimers' advanced MLB model predicts the Yankees as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's White Sox-Yankees game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Yankees' chance of winning at 74%, with the White Sox at 26%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive White Sox vs. Yankees predictions page.

Yankees vs. White Sox prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the White Sox and Yankees 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Yankees a 74% chance of beating the White Sox.

According to our model, the Yankees (-1.5) have a 56% chance of covering the run line, while the 8-run over/under has a 56% chance of going over.

White Sox vs. Yankees odds [9/24/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Yankees
Run Line	+1.5 (+140)	-1.5 (-170)
Moneyline	+310	-375
Total	o8 (-114)	u8 (-103)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Yankees picks and best bets

Our model's biggest edge in today's White Sox vs. Yankees matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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White Sox vs. Yankees game-day updates and essential details

Wednesday's MLB action between the Yankees and White Sox at Yankee Stadium is scheduled to commence at 7:05PM ET.

• Who: Chicago White Sox vs. New York Yankees
• Date: Wednesday, September 24, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Yankee Stadium

Dimers' full preview of Wednesday's White Sox vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Yankees, with a 74% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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