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White Sox vs. Yankees prediction: Yankees favored to win Tuesday's MLB matchup [9/23/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Chicago White Sox vs New York Yankees predictions for MLB Tuesday.
The New York Yankees and Chicago whitesox will meet in MLB action at Yankee Stadium on Tuesday, starting at 7:05PM ET.
The Yankees will send Luis Gil (4-1, 3.33 ERA) to the mound, pitting him against Shane Smith (6-8, 4.06 ERA) for the White Sox.
Based on updated simulations, Dimers' proven MLB model projects the Yankees as the most likely winner of today's game.
For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive White Sox vs. Yankees predictions page.
Yankees vs. White Sox prediction: Who will win, cover the run line?
Using trusted machine learning and statistical analysis, we have simulated the result of Tuesday's MLB game between the White Sox and Yankees 10,000 times as part of our MLB predictions coverage.
Our famous predictive model currently gives the Yankees a 68% chance of defeating the White Sox.
According to our model, the Yankees (-1.5) have a 51% chance of covering the run line, while the over/under total of 9 runs has a 51% chance of going over.
White Sox vs. Yankees odds [9/23/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | White Sox | Yankees |
|---|---|---|
| Run Line | +1.5 (+110) | -1.5 (-119) |
| Moneyline | +200 | -235 |
| Total | o9 (-102) | u9 (-120) |
All odds are correct at the time of publication and are subject to change.
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White Sox vs. Yankees picks and best bets
Our model's strongest edge in today's White Sox vs. Yankees matchup is on the total.
Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's best bets
Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.
White Sox vs. Yankees game-day updates and essential details
Tuesday's MLB game between the Yankees and White Sox at Yankee Stadium is scheduled to start at 7:05PM ET.
- Who: Chicago White Sox vs. New York Yankees
- Date: Tuesday, September 23, 2025
- Time: 7:05PM ET/4:05PM PT
- Venue: Yankee Stadium
Dimers' in-depth preview of Tuesday's White Sox vs. Yankees matchup includes our prediction, picks and the latest betting odds.
Before making any White Sox vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Yankees, with a 68% win probability, will likely beat the White Sox on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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