White Sox vs. Yankees prediction: Yankees favored to win Thursday's MLB matchup [9/25/2025]

MLB action continues on Thursday at 7:05PM ET as the Chicago White Sox take on the New York Yankees at Yankee Stadium.

Carlos Rodón (17-9, 3.04 ERA) will get the ball for the Yankees, pitting him against Davis Martin (7-10, 4.03 ERA) for the White Sox.

Based on updated simulations, Dimers' advanced MLB model predicts the Yankees as the most likely winner of today's game.

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive White Sox vs. Yankees predictions page.

Yankees vs. White Sox prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Thursday's MLB game between the White Sox and Yankees 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Yankees a 74% chance of beating the White Sox.

According to our model, the Yankees (-1.5) have a 57% chance of covering the run line, while the 8.5-run over/under has a 56% chance of going over.

White Sox vs. Yankees odds [9/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Yankees
Run Line	+1.5 (+126)	-1.5 (-152)
Moneyline	+250	-295
Total	o8.5 (-120)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Yankees picks and best bets

Our model's biggest edge in today's White Sox vs. Yankees matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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White Sox vs. Yankees game-day updates and essential details

Thursday's MLB game between the Yankees and White Sox at Yankee Stadium is scheduled to commence at 7:05PM ET.

• Who: Chicago White Sox vs. New York Yankees
• Date: Thursday, September 25, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Yankee Stadium

Dimers' comprehensive preview of Thursday's White Sox vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Yankees, with a 74% win probability, will likely beat the White Sox on Thursday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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