White Sox vs. Twins prediction: Why Minnesota is favored to win Wednesday's MLB matchup [9/3/2025]

The Minnesota Twins and Chicago whitesox will lock horns in MLB action at Target Field on Wednesday, starting at 7:40PM ET.

Zebby Matthews (4-4, 5.06 ERA) will start on the mound for the Twins, up against Yoendrys Gómez (3-2, 5.20 ERA) for the White Sox.

Based on updated simulations, Dimers' proven MLB model predicts the Twins as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's White Sox-Twins game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Twins' chance of winning at 61%, with the White Sox at 39%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive White Sox vs. Twins predictions page.

Twins vs. White Sox prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB matchup between the White Sox and Twins 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Twins a 61% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 57% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

White Sox vs. Twins odds [9/3/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Twins
Run Line	+1.5 (-140)	-1.5 (+125)
Moneyline	+145	-158
Total	o8.5 (-109)	u8.5 (-106)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Twins picks and best bets

Our model's biggest edge in today's White Sox vs. Twins matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

White Sox vs. Twins game-day updates and essential details

Wednesday's MLB action between the Twins and White Sox at Target Field is scheduled to start at 7:40PM ET.

• Who: Chicago White Sox vs. Minnesota Twins
• Date: Wednesday, September 3, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Target Field

Dimers.com's full preview of Wednesday's White Sox vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Twins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Twins, with a 61% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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