White Sox vs. Royals Prediction: Kansas City Predicted to Win Tuesday's MLB Matchup [5/6/2025]

The Kansas City Royals and Chicago whitesox are scheduled to meet in MLB action at Kauffman Stadium on Tuesday, starting at 7:40PM ET.

The Royals will send Seth Lugo (3-3, 3.07 ERA) to the mound, while the White Sox have opted for Sean Burke (2-4, 4.91 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Royals as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's CHI White Sox-Kansas City game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Royals with a win probability of 67%, compared to 33% for the White Sox."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive White Sox vs. Royals predictions page.

Royals vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Tuesday's MLB matchup between the White Sox and Royals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Royals a 67% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 54% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of staying under.

White Sox vs. Royals Odds [5/6/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Royals
Run Line	+1.5 (-102)	-1.5 (-114)
Moneyline	+210	-250
Total	o8.5 (-110)	u8.5 (-108)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Royals Picks and Best Bets

Our model's strongest edge in today's White Sox vs. Royals matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

White Sox vs. Royals Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Royals and White Sox at Kauffman Stadium is scheduled to commence at 7:40PM ET.

• Who: Chicago White Sox vs. Kansas City Royals
• Date: Tuesday, May 6, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Kauffman Stadium

Dimers.com's comprehensive preview of Tuesday's White Sox vs. Royals matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. Kansas City picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Royals, with a 67% win probability, will likely beat the White Sox on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Royals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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