White Sox vs. Tigers prediction: Detroit favored to win Saturday's MLB matchup [9/6/2025]

The Detroit Tigers will face the Chicago White Sox in MLB action at Comerica Park on Saturday, commencing at 6:10PM ET.

Tarik Skubal (12-4, 2.18 ERA) will be the starting pitcher for the Tigers, while the White Sox have opted for Martín Pérez (1-3, 2.16 ERA).

Based on the latest simulations, Dimers' proven MLB model predicts the Tigers as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive White Sox vs. Tigers predictions page.

Tigers vs. White Sox prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the outcome of Saturday's MLB game between the White Sox and Tigers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Tigers a 71% chance of beating the White Sox.

According to our model, the Tigers (-1.5) have a 52% chance of covering the run line, while the 7-run over/under has a 52% chance of going over.

White Sox vs. Tigers odds [9/6/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Tigers
Run Line	+1.5 (+115)	-1.5 (-138)
Moneyline	+246	-300
Total	o7 (-122)	u7 (+105)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Tigers picks and best bets

Our model's biggest edge in today's White Sox vs. Tigers matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

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White Sox vs. Tigers game-day updates and essential details

Saturday's MLB action between the Tigers and White Sox at Comerica Park is scheduled to start at 6:10PM ET.

• Who: Chicago White Sox vs. Detroit Tigers
• Date: Saturday, September 6, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Comerica Park

Dimers.com's comprehensive preview of Saturday's White Sox vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 71% win probability, will likely beat the White Sox on Saturday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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