White Sox vs. Tigers prediction: Detroit favored to win Friday's MLB matchup [9/5/2025]

The Detroit Tigers and Chicago whitesox are scheduled to meet in MLB action at Comerica Park on Friday, starting at 6:40PM ET.

The Tigers will send Jack Flaherty (7-13, 4.74 ERA) to the mound, while the White Sox have opted for Shane Smith (4-7, 3.81 ERA).

Based on updated simulation results, Dimers' proven MLB model predicts the Tigers as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive White Sox vs. Tigers predictions page.

Tigers vs. White Sox prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Friday's MLB game between the White Sox and Tigers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Tigers a 64% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 55% chance of covering the run line, while the 8.5-run over/under has a 52% chance of staying under.

White Sox vs. Tigers odds [9/5/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Tigers
Run Line	+1.5 (-118)	-1.5 (+105)
Moneyline	+168	-199
Total	o8.5 (-105)	u8.5 (-109)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Tigers picks and best bets

Our model's strongest edge in today's White Sox vs. Tigers matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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White Sox vs. Tigers game-day updates and essential details

Friday's MLB game between the Tigers and White Sox at Comerica Park is scheduled to commence at 6:40PM ET.

• Who: Chicago White Sox vs. Detroit Tigers
• Date: Friday, September 5, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Comerica Park

Dimers.com's comprehensive preview of Friday's White Sox vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 64% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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