White Sox vs. Guardians prediction: Why Cleveland is favored to win Sunday's MLB matchup [9/14/2025]

The Cleveland Guardians will take on the Chicago White Sox in MLB action at Progressive Field on Sunday, starting at 1:40PM ET.

The Guardians will send Slade Cecconi (6-6, 4.45 ERA) to the mound, while the White Sox are going with Yoendrys Gómez (3-2, 5.05 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts the Guardians as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's White Sox-Guardians game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Guardians with a win probability of 58%, while the White Sox have 42%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive White Sox vs. Guardians predictions page.

Guardians vs. White Sox prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the outcome of Sunday's MLB game between the White Sox and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Guardians a 58% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 61% chance of covering the run line, while the 8-run over/under has a 52% chance of going over.

White Sox vs. Guardians odds [9/14/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Guardians
Run Line	+1.5 (-160)	-1.5 (+136)
Moneyline	+140	-158
Total	o8 (+100)	u8 (-119)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Guardians picks and best bets

Our model's biggest edge in today's White Sox vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

White Sox vs. Guardians game-day updates and essential details

Sunday's MLB game between the Guardians and White Sox at Progressive Field is scheduled to start at 1:40PM ET.

• Who: Chicago White Sox vs. Cleveland Guardians
• Date: Sunday, September 14, 2025
• Time: 1:40PM ET/10:40AM PT
• Venue: Progressive Field

Dimers' in-depth preview of Sunday's White Sox vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 58% win probability, will likely beat the White Sox on Sunday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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