White Sox vs. Guardians prediction: Why Cleveland is favored to win Saturday's MLB matchup [9/13/2025]

The Cleveland Guardians will square off with the Chicago White Sox in MLB action at Progressive Field on Saturday, starting at 6:10PM ET.

Parker Messick (2-0, 1.93 ERA) will get the ball for the Guardians, up against Davis Martin (6-9, 4.03 ERA) for the White Sox.

Based on updated simulation results, Dimers' proven MLB model projects the Guardians as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive White Sox vs. Guardians predictions page.

Guardians vs. White Sox prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Saturday's MLB game between the White Sox and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Guardians a 61% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 58% chance of covering the run line, while the over/under total of 7.5 runs has a 54% chance of going over.

White Sox vs. Guardians odds [9/13/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Guardians
Run Line	+1.5 (-144)	-1.5 (+130)
Moneyline	+148	-165
Total	o7.5 (-110)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Guardians picks and best bets

Our model's strongest edge in today's White Sox vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

White Sox vs. Guardians game-day updates and essential details

Saturday's MLB game between the Guardians and White Sox at Progressive Field is scheduled to begin at 6:10PM ET.

• Who: Chicago White Sox vs. Cleveland Guardians
• Date: Saturday, September 13, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Progressive Field

Dimers' full preview of Saturday's White Sox vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 61% win probability, will likely beat the White Sox on Saturday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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