White Sox vs. Guardians prediction: Why Cleveland is favored to win Friday's MLB matchup [9/12/2025]

MLB action continues on Friday at 7:10PM ET as the Chicago White Sox lock horns with the Cleveland Guardians at Progressive Field.

Tanner Bibee (9-11, 4.69 ERA) will start on the mound for the Guardians, while the White Sox are going with Martín Pérez (1-4, 3.15 ERA).

Based on updated simulations, Dimers' advanced MLB model predicts the Guardians as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive White Sox vs. Guardians predictions page.

Guardians vs. White Sox prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB game between the White Sox and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Guardians a 55% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 63% chance of covering the run line, while the 7.5-run over/under has a 53% chance of going over.

White Sox vs. Guardians odds [9/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Guardians
Run Line	+1.5 (-176)	-1.5 (+150)
Moneyline	+123	-140
Total	o7.5 (-110)	u7.5 (-109)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Guardians picks and best bets

Our model's biggest edge in today's White Sox vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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White Sox vs. Guardians game-day updates and essential details

Friday's MLB matchup between the Guardians and White Sox at Progressive Field is scheduled to start at 7:10PM ET.

• Who: Chicago White Sox vs. Cleveland Guardians
• Date: Friday, September 12, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Progressive Field

Dimers' comprehensive preview of Friday's White Sox vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any White Sox vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 55% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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