White Sox vs. Cubs Prediction: Cubs Predicted to Win Sunday's MLB Matchup [5/18/2025]

MLB action continues on Sunday at 2:20PM ET as the Chicago White Sox take on the favored Chicago Cubs at Wrigley Field.

Colin Rea (3-0, 2.48 ERA) will start for the Cubs, while the White Sox are going with Jonathan Cannon (2-4, 3.60 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's CHI White Sox-CHI Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cubs with a win probability of 68%, while the White Sox have 32%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive White Sox vs. Cubs predictions page.

Cubs vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Sunday's MLB game between the White Sox and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cubs a 68% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 53% chance of covering the run line, while the over/under total of 8.5 runs has a 58% chance of staying under.

White Sox vs. Cubs Odds [5/18/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Cubs
Run Line	+1.5 (+100)	-1.5 (+104)
Moneyline	+240	-205
Total	o8.5 (+100)	u8.5 (-125)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Cubs Picks and Best Bets

Our model's strongest edge in today's White Sox vs. Cubs matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

White Sox vs. Cubs Game-Day Updates and Essential Details

Sunday's MLB matchup between the Cubs and White Sox at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Chicago White Sox vs. Chicago Cubs
• Date: Sunday, May 18, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's full preview of Sunday's White Sox vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cubs, with a 68% win probability, will likely beat the White Sox on Sunday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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