White Sox vs. Cubs Prediction: Cubs Predicted to Win Saturday's MLB Matchup [5/17/2025]

MLB action continues on Saturday at 2:20PM ET as the Chicago White Sox take on the favored Chicago Cubs at Wrigley Field.

The Cubs will have Matthew Boyd (3-2, 2.78 ERA) as their starting pitcher, while the White Sox have opted for Sean Burke (2-4, 4.15 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's CHI White Sox-CHI Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Cubs are more likely to win, while the White Sox have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive White Sox vs. Cubs predictions page.

Cubs vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Saturday's MLB game between the White Sox and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cubs a 70% chance of defeating the White Sox.

According to our model, the Cubs (-1.5) have a 53% chance of covering the run line, while the over/under total of 10 runs has a 57% chance of staying under.

White Sox vs. Cubs Odds [5/17/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Cubs
Run Line	+1.5 (+134)	-1.5 (-162)
Moneyline	+260	-300
Total	o10 (-105)	u10 (-115)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Cubs Picks and Best Bets

Our model's biggest edge in today's White Sox vs. Cubs matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

White Sox vs. Cubs Game-Day Updates and Essential Details

Saturday's MLB action between the Cubs and White Sox at Wrigley Field is scheduled to begin at 2:20PM ET.

• Who: Chicago White Sox vs. Chicago Cubs
• Date: Saturday, May 17, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Saturday's White Sox vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 70% win probability, will likely beat the White Sox on Saturday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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