White Sox vs. Cubs Prediction: Cubs Predicted to Win Friday's MLB Matchup [5/16/2025]

MLB action continues on Friday at 2:20PM ET as the Chicago White Sox square off with the Chicago Cubs at Wrigley Field.

The Cubs will have Cade Horton (1-0, 6.75 ERA) as their starting pitcher, pitting him against Shane Smith (1-2, 2.08 ERA) for the White Sox.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's CHI White Sox-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cubs' chance of winning is 66%, while the White Sox' is 34%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive White Sox vs. Cubs predictions page.

Cubs vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the White Sox and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 66% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 52% chance of covering the run line, while the 11.5-run over/under has a 60% chance of staying under.

White Sox vs. Cubs Odds [5/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Cubs
Run Line	+1.5 (-105)	-1.5 (+102)
Moneyline	+185	-200
Total	o11.5 (-105)	u11.5 (-105)

All odds are correct at the time of publication and are subject to change.

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White Sox vs. Cubs Picks and Best Bets

Our model's strongest edge in today's White Sox vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

White Sox vs. Cubs Game-Day Updates and Essential Details

Friday's MLB game between the Cubs and White Sox at Wrigley Field is scheduled to begin at 2:20PM ET.

• Who: Chicago White Sox vs. Chicago Cubs
• Date: Friday, May 16, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's full preview of Friday's White Sox vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cubs, with a 66% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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