Cubs vs. Nationals Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [6/4/2025]

The Washington Nationals and Chicago Cubs will meet in MLB action at Nationals Park on Wednesday, starting at 6:45PM ET.

MacKenzie Gore (2-5, 3.16 ERA) will be the starting pitcher for the Nationals, while the Cubs have opted for Matthew Boyd (5-2, 3.08 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's CHI Cubs-Washington game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 55%, with the Nationals at 45%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Cubs vs. Nationals predictions page.

Nationals vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Cubs and Nationals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 55% chance of beating the Nationals.

According to our model, the Nationals (+1.5) have a 59% chance of covering the run line, while the 8-run over/under has a 52% chance of staying under.

Cubs vs. Nationals Odds [6/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Nationals
Run Line	-1.5 (+120)	+1.5 (-140)
Moneyline	-138	+120
Total	o8 (-115)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cubs vs. Nationals Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Nationals matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cubs vs. Nationals Game-Day Updates and Essential Details

Wednesday's MLB action between the Nationals and Cubs at Nationals Park is scheduled to start at 6:45PM ET.

• Who: Chicago Cubs vs. Washington Nationals
• Date: Wednesday, June 4, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Nationals Park

Dimers.com's full preview of Wednesday's Cubs vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Cubs, with a 55% win probability, will likely beat the Nationals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate projections for the World Series, American League, National League and each division.