Cubs vs. Nationals Prediction: Cubs Predicted to Win Thursday's MLB Matchup [6/5/2025]

The Washington Nationals will face the Chicago Cubs in MLB action at Nationals Park on Thursday, beginning at 6:45PM ET.

Jake Irvin (5-1, 3.93 ERA) will get the ball for the Nationals, pitting him against Drew Pomeranz (2-0, 0.00 ERA) for the Cubs.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's CHI Cubs-Washington game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Cubs with a win probability of 57% and the Nationals with 43%."

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Cubs vs. Nationals predictions page.

Nationals vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Thursday's MLB matchup between the Cubs and Nationals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 57% chance of defeating the Nationals.

According to our model, the Nationals (+1.5) have a 54% chance of covering the run line, while the over/under total of 10 runs has a 56% chance of staying under.

Cubs vs. Nationals Odds [6/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Nationals
Run Line	-1.5 (+110)	+1.5 (-120)
Moneyline	-148	+130
Total	o10 (-102)	u10 (-118)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Nationals Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Nationals matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cubs vs. Nationals Game-Day Updates and Essential Details

Thursday's MLB matchup between the Nationals and Cubs at Nationals Park is scheduled to commence at 6:45PM ET.

• Who: Chicago Cubs vs. Washington Nationals
• Date: Thursday, June 5, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Nationals Park

Dimers.com's full preview of Thursday's Cubs vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cubs, with a 57% win probability, will likely beat the Nationals on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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