Cubs vs. Cardinals Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [6/25/2025]

The St. Louis Cardinals will take on the Chicago Cubs in MLB action at Busch Stadium on Wednesday, starting at 7:45PM ET.

Erick Fedde (3-6, 3.54 ERA) will start for the Cardinals, pitting him against Matthew Boyd (6-3, 2.84 ERA) for the Cubs.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cubs-Cardinals game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 57%, with the Cardinals at 43%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Cubs vs. Cardinals predictions page.

Cardinals vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Cubs and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cubs a 57% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 56% chance of covering the run line, while the over/under total of 9 runs has a 56% chance of staying under.

Cubs vs. Cardinals Odds [6/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Cardinals
Run Line	-1.5 (+110)	+1.5 (-126)
Moneyline	-150	+132
Total	o9 (-102)	u9 (-119)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cubs vs. Cardinals Game-Day Updates and Essential Details

Wednesday's MLB game between the Cardinals and Cubs at Busch Stadium is scheduled to start at 7:45PM ET.

• Who: Chicago Cubs vs. St. Louis Cardinals
• Date: Wednesday, June 25, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Wednesday's Cubs vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Cubs, with a 57% win probability, will likely beat the Cardinals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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