Cubs vs. Cardinals Prediction: Cubs Predicted to Win Thursday's MLB Matchup [6/26/2025]

The St. Louis Cardinals will take on the Chicago Cubs in MLB action at Busch Stadium on Thursday, starting at 2:15PM ET.

The Cardinals will have Andre Pallante (5-3, 4.48 ERA) as their starting pitcher, up against Shota Imanaga (3-2, 2.82 ERA) for the Cubs.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Cubs-Cardinals game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Cubs with a win probability of 54% and the Cardinals with 46%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Cubs vs. Cardinals predictions page.

Cardinals vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Thursday's MLB matchup between the Cubs and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 54% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 59% chance of covering the run line, while the over/under total of 9 runs has a 54% chance of staying under.

Cubs vs. Cardinals Odds [6/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Cardinals
Run Line	-1.5 (+120)	+1.5 (-142)
Moneyline	-134	+115
Total	o9 (-118)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cubs vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Cubs vs. Cardinals Game-Day Updates and Essential Details

Thursday's MLB game between the Cardinals and Cubs at Busch Stadium is scheduled to begin at 2:15PM ET.

• Who: Chicago Cubs vs. St. Louis Cardinals
• Date: Thursday, June 26, 2025
• Time: 2:15PM ET/11:15AM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Thursday's Cubs vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with sports betting in Missouri set to launch on December 1, 2025, Dimers has everything you need—from the latest news and the best Missouri sports betting promos.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Cubs, with a 54% win probability, will likely beat the Cardinals on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most up-to-date probabilities for the World Series, American League, National League and each division.