Cubs vs. Cardinals Prediction: Cubs Predicted to Win Monday's MLB Matchup [6/23/2025]

The St. Louis Cardinals and Chicago Cubs will lock horns in MLB action at Busch Stadium on Monday, starting at 7:45PM ET.

The Cardinals will send Matthew Liberatore (4-6, 4.08 ERA) to the mound, while the Cubs will counter with Ben Brown (4-5, 5.57 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Cubs-Cardinals game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Cubs are likely to win, with a probability of 53%, compared to the Cardinals' 47%."

For further insights into Monday's matchup, including best bets and picks, visit our interactive Cubs vs. Cardinals predictions page.

Cardinals vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Cubs and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cubs a 53% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Cubs vs. Cardinals Odds [6/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Cardinals
Run Line	-1.5 (+145)	+1.5 (-154)
Moneyline	-115	+102
Total	o8.5 (-120)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Cardinals matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cubs vs. Cardinals Game-Day Updates and Essential Details

Monday's MLB action between the Cardinals and Cubs at Busch Stadium is scheduled to commence at 7:45PM ET.

• Who: Chicago Cubs vs. St. Louis Cardinals
• Date: Monday, June 23, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Monday's Cubs vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Cubs, with a 53% win probability, will likely beat the Cardinals on Monday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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