Cubs vs. Cardinals Prediction: Cubs Predicted to Win Friday's MLB Matchup [8/8/2025]

The St. Louis Cardinals will face the Chicago Cubs in MLB action at Busch Stadium on Friday, starting at 8:15PM ET.

The Cardinals will start Michael McGreevy (3-2, 5.08 ERA), up against Matthew Boyd (11-4, 2.34 ERA) for the Cubs.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Cubs vs. Cardinals predictions page.

Cardinals vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Friday's MLB game between the Cubs and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 59% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 54% chance of covering the run line, while the 8.5-run over/under has a 51% chance of staying under.

Cubs vs. Cardinals Odds [8/8/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Cardinals
Run Line	-1.5 (+100)	+1.5 (-118)
Moneyline	-165	+144
Total	o8.5 (-105)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Cardinals matchup is on the total.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Cubs vs. Cardinals Game-Day Updates and Essential Details

Friday's MLB game between the Cardinals and Cubs at Busch Stadium is scheduled to begin at 8:15PM ET.

• Who: Chicago Cubs vs. St. Louis Cardinals
• Date: Friday, August 8, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Friday's Cubs vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 59% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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