Cubs vs. Giants prediction: Cubs favored to win Wednesday's MLB matchup [8/27/2025]

The San Francisco Giants will take on the Chicago Cubs in MLB action at Oracle Park on Wednesday, starting at 9:45PM ET.

Carson Whisenhunt (1-1, 4.91 ERA) will start on the mound for the Giants, while the Cubs are going with Colin Rea (10-5, 3.96 ERA).

Based on the latest simulations, Dimers' proven MLB model projects the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cubs-Giants game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 53%, with the Giants at 47%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Cubs vs. Giants predictions page.

Giants vs. Cubs prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Cubs and Giants 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 53% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 59% chance of covering the run line, while the 8.5-run over/under has a 51% chance of going over.

Cubs vs. Giants odds [8/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Giants
Run Line	-1.5 (+128)	+1.5 (-150)
Moneyline	-130	+110
Total	o8.5 (-115)	u8.5 (-103)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Giants picks and best bets

Our model's strongest edge in today's Cubs vs. Giants matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Cubs vs. Giants game-day updates and essential details

Wednesday's MLB game between the Giants and Cubs at Oracle Park is scheduled to start at 9:45PM ET.

• Who: Chicago Cubs vs. San Francisco Giants
• Date: Wednesday, August 27, 2025
• Time: 9:45PM ET/6:45PM PT
• Venue: Oracle Park

Dimers.com's full preview of Wednesday's Cubs vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 53% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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