Cubs vs. Giants prediction: Cubs favored to win Tuesday's MLB matchup [8/26/2025]

The San Francisco Giants will take on the Chicago Cubs in MLB action at Oracle Park on Tuesday, starting at 9:45PM ET.

Justin Verlander (1-10, 4.64 ERA) will get the ball for the Giants, while the Cubs have opted for Matthew Boyd (12-6, 2.62 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Cubs as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Cubs vs. Giants predictions page.

Giants vs. Cubs prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Tuesday's MLB game between the Cubs and Giants 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cubs a 57% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 57% chance of covering the run line, while the 7.5-run over/under has a 52% chance of going over.

Cubs vs. Giants odds [8/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Giants
Run Line	-1.5 (+122)	+1.5 (-145)
Moneyline	-146	+131
Total	o7.5 (-115)	u7.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Giants picks and best bets

Our model's biggest edge in today's Cubs vs. Giants matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cubs vs. Giants game-day updates and essential details

Tuesday's MLB action between the Giants and Cubs at Oracle Park is scheduled to commence at 9:45PM ET.

• Who: Chicago Cubs vs. San Francisco Giants
• Date: Tuesday, August 26, 2025
• Time: 9:45PM ET/6:45PM PT
• Venue: Oracle Park

Dimers.com's comprehensive preview of Tuesday's Cubs vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 57% win probability, will likely beat the Giants on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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