Cubs vs. Giants prediction: San Francisco favored to win Thursday's MLB matchup [8/28/2025]

The San Francisco Giants will take on the Chicago Cubs in MLB action at Oracle Park on Thursday, starting at 3:45PM ET.

Logan Webb (12-9, 3.13 ERA) will start for the Giants, up against Shota Imanaga (8-6, 3.03 ERA) for the Cubs.

Based on the latest simulations, Dimers' advanced MLB model predicts the Giants as the most likely winner of today's game.

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Cubs vs. Giants predictions page.

Giants vs. Cubs prediction: Who will win?

Using powerful machine learning and data, we have simulated the result of Thursday's MLB game between the Cubs and Giants 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Giants a 51% chance of beating the Cubs.

According to our model, the 7.5-run over/under has a 52% chance of staying under.

Cubs vs. Giants odds [8/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Giants
Moneyline	-101	-112
Total	o7.5 (+102)	u7.5 (-124)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Giants picks and best bets

Our model's strongest edge in today's Cubs vs. Giants matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Cubs vs. Giants game-day updates and essential details

Thursday's MLB game between the Giants and Cubs at Oracle Park is scheduled to begin at 3:45PM ET.

• Who: Chicago Cubs vs. San Francisco Giants
• Date: Thursday, August 28, 2025
• Time: 3:45PM ET/12:45PM PT
• Venue: Oracle Park

Dimers.com's full preview of Thursday's Cubs vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Giants, with a 51% win probability, will likely beat the Cubs on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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