Cubs vs. Pirates prediction: Why Cubs are favored to win Wednesday's MLB matchup [9/17/2025]

The Pittsburgh Pirates will face the Chicago Cubs in MLB action at PNC Park on Wednesday, beginning at 12:35PM ET.

Johan Oviedo (2-0, 2.80 ERA) will start on the mound for the Pirates, while the Cubs have opted for Matthew Boyd (13-8, 3.05 ERA).

Based on the latest simulations, Dimers' advanced MLB model predicts the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cubs-Pirates game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 55%, with the Pirates at 45%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Cubs vs. Pirates predictions page.

Pirates vs. Cubs prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Cubs and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cubs a 55% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 58% chance of covering the run line, while the over/under total of 7.5 runs has a 53% chance of going over.

Cubs vs. Pirates odds [9/17/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Pirates
Run Line	-1.5 (+125)	+1.5 (-139)
Moneyline	-140	+122
Total	o7.5 (-115)	u7.5 (-103)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Pirates picks and best bets

Our model's strongest edge in today's Cubs vs. Pirates matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cubs vs. Pirates game-day updates and essential details

Wednesday's MLB matchup between the Pirates and Cubs at PNC Park is scheduled to start at 12:35PM ET.

• Who: Chicago Cubs vs. Pittsburgh Pirates
• Date: Wednesday, September 17, 2025
• Time: 12:35PM ET/9:35AM PT
• Venue: PNC Park

Dimers' full preview of Wednesday's Cubs vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Pirates picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 55% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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