Cubs vs. Pirates prediction: Why Cubs are favored to win Monday's MLB matchup [9/15/2025]

The Pittsburgh Pirates will square off with the Chicago Cubs in MLB action at PNC Park on Monday, starting at 6:40PM ET.

Braxton Ashcraft (4-2, 2.47 ERA) will be on the bump for the Pirates, while the Cubs have opted for Jameson Taillon (9-6, 4.15 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts the Cubs as the most likely winner of today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Cubs vs. Pirates predictions page.

Pirates vs. Cubs prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Monday's MLB game between the Cubs and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 52% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 61% chance of covering the run line, while the over/under total of 8 runs has a 52% chance of going over.

Cubs vs. Pirates odds [9/15/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Pirates
Run Line	-1.5 (+141)	+1.5 (-152)
Moneyline	-119	+106
Total	o8 (-105)	u8 (-112)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Pirates picks and best bets

Our model's biggest edge in today's Cubs vs. Pirates matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Cubs vs. Pirates game-day updates and essential details

Monday's MLB matchup between the Pirates and Cubs at PNC Park is scheduled to begin at 6:40PM ET.

• Who: Chicago Cubs vs. Pittsburgh Pirates
• Date: Monday, September 15, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers' full preview of Monday's Cubs vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Pirates picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 52% win probability, will likely beat the Pirates on Monday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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