Cubs vs. Pirates Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [4/30/2025]

The Pittsburgh Pirates and Chicago Cubs are scheduled to meet in MLB action at PNC Park on Wednesday, starting at 6:40PM ET.

Carmen Mlodzinski (1-3, 6.96 ERA) will start for the Pirates, while the Cubs are going with Matthew Boyd (2-2, 2.54 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's CHI Cubs-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 60%, with the Pirates at 40%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Cubs vs. Pirates predictions page.

Pirates vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Cubs and Pirates 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 60% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 53% chance of covering the run line, while the 9-run over/under has a 54% chance of staying under.

Cubs vs. Pirates Odds [4/30/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Pirates
Run Line	-1.5 (-105)	+1.5 (-110)
Moneyline	-170	+148
Total	o9 (-102)	u9 (-118)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Pirates Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Pirates matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cubs vs. Pirates Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Pirates and Cubs at PNC Park is scheduled to begin at 6:40PM ET.

• Who: Chicago Cubs vs. Pittsburgh Pirates
• Date: Wednesday, April 30, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's full preview of Wednesday's Cubs vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cubs, with a 60% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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