Cubs vs. Pirates Prediction: Cubs Predicted to Win Tuesday's MLB Matchup [4/29/2025]

The Pittsburgh Pirates will square off with the Chicago Cubs in MLB action at PNC Park on Tuesday, starting at 6:40PM ET.

Andrew Heaney (2-1, 1.72 ERA) will be on the bump for the Pirates, up against Shota Imanaga (2-1, 3.18 ERA) for the Cubs.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's CHI Cubs-Pittsburgh game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Cubs with a win probability of 57%, compared to 43% for the Pirates."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Cubs vs. Pirates predictions page.

Pirates vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Cubs and Pirates 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 57% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 56% chance of covering the run line, while the 9-run over/under has a 58% chance of staying under.

Cubs vs. Pirates Odds [4/29/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Pirates
Run Line	-1.5 (+110)	+1.5 (-128)
Moneyline	-148	+130
Total	o9 (-105)	u9 (-115)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Pirates Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Pirates matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cubs vs. Pirates Game-Day Updates and Essential Details

Tuesday's MLB game between the Pirates and Cubs at PNC Park is scheduled to commence at 6:40PM ET.

• Who: Chicago Cubs vs. Pittsburgh Pirates
• Date: Tuesday, April 29, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's in-depth preview of Tuesday's Cubs vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cubs, with a 57% win probability, will likely beat the Pirates on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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