Cubs vs. Marlins Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [5/21/2025]

The Miami Marlins and Chicago Cubs will lock horns in MLB action at loanDepot park on Wednesday, starting at 1:10PM ET.

Max Meyer (3-4, 4.47 ERA) will start on the mound for the Marlins, while the Cubs have opted for Cade Horton (2-0, 6.00 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's CHI Cubs-Miami game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 55%, with the Marlins at 45%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Cubs vs. Marlins predictions page.

Marlins vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Wednesday's MLB game between the Cubs and Marlins 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 55% chance of beating the Marlins.

According to our model, the Marlins (+1.5) have a 58% chance of covering the run line, while the 9-run over/under has a 54% chance of staying under.

Cubs vs. Marlins Odds [5/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Marlins
Run Line	-1.5 (+114)	+1.5 (-125)
Moneyline	-146	+125
Total	o9 (-110)	u9 (-102)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Marlins Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Marlins matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cubs vs. Marlins Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Marlins and Cubs at loanDepot park is scheduled to begin at 1:10PM ET.

• Who: Chicago Cubs vs. Miami Marlins
• Date: Wednesday, May 21, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: loanDepot park

Dimers.com's in-depth preview of Wednesday's Cubs vs. Marlins matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Miami picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Cubs, with a 55% win probability, will likely beat the Marlins on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Marlins insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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