Cubs vs. Angels prediction: Cubs favored to win Saturday's MLB matchup [8/23/2025]

The Los Angeles Angels and Chicago Cubs are scheduled to meet in MLB action at Angel Stadium on Saturday, starting at 9:38PM ET.

Victor Mederos (0-1, 5.54 ERA) will start on the mound for the Angels, pitting him against Cade Horton (7-4, 3.08 ERA) for the Cubs.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Cubs as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Cubs vs. Angels predictions page.

Angels vs. Cubs prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Saturday's MLB game between the Cubs and Angels 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 58% chance of defeating the Angels.

According to our model, the Angels (+1.5) have a 54% chance of covering the run line, while the 9.5-run over/under has an equal 50-50 chance of hitting.

Cubs vs. Angels odds [8/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Angels
Run Line	-1.5 (+104)	+1.5 (-118)
Moneyline	-146	+130
Total	o9.5 (-118)	u9.5 (+102)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Angels picks and best bets

Our model's biggest edge in today's Cubs vs. Angels matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Cubs vs. Angels game-day updates and essential details

Saturday's MLB game between the Angels and Cubs at Angel Stadium is scheduled to start at 9:38PM ET.

• Who: Chicago Cubs vs. Los Angeles Angels
• Date: Saturday, August 23, 2025
• Time: 9:38PM ET/6:38PM PT
• Venue: Angel Stadium

Dimers.com's in-depth preview of Saturday's Cubs vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 58% win probability, will likely beat the Angels on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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