Cubs vs. Angels prediction: Cubs favored to win Friday's MLB matchup [8/22/2025]

The Los Angeles Angels will take on the Chicago Cubs in MLB action at Angel Stadium on Friday, beginning at 9:38PM ET.

The Angels will have Tyler Anderson (2-8, 4.77 ERA) as their starting pitcher, pitting him against Javier Assad (0-1, 5.62 ERA) for the Cubs.

Based on updated simulation results, Dimers' advanced MLB model predicts the Cubs as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Cubs vs. Angels predictions page.

Angels vs. Cubs prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Friday's MLB game between the Cubs and Angels 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 53% chance of defeating the Angels.

According to our model, the Angels (+1.5) have a 58% chance of covering the run line, while the 9.5-run over/under has a 52% chance of staying under.

Cubs vs. Angels odds [8/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Angels
Run Line	-1.5 (+125)	+1.5 (-146)
Moneyline	-126	+114
Total	o9.5 (-112)	u9.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Angels picks and best bets

Our model's strongest edge in today's Cubs vs. Angels matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Cubs vs. Angels game-day updates and essential details

Friday's MLB action between the Angels and Cubs at Angel Stadium is scheduled to begin at 9:38PM ET.

• Who: Chicago Cubs vs. Los Angeles Angels
• Date: Friday, August 22, 2025
• Time: 9:38PM ET/6:38PM PT
• Venue: Angel Stadium

Dimers.com's comprehensive preview of Friday's Cubs vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 53% win probability, will likely beat the Angels on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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