Cubs vs. Astros Prediction: Houston Predicted to Win Sunday's MLB Matchup [6/29/2025]

MLB action continues on Sunday at 2:10PM ET as the Chicago Cubs take on the Houston Astros at Daikin Park.

The Astros will start Framber Valdez (8-4, 2.88 ERA), up against Jameson Taillon (7-5, 4.47 ERA) for the Cubs.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cubs-Astros game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Astros with a win probability of 58%, while the Cubs have 42%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Cubs vs. Astros predictions page.

Astros vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Sunday's MLB game between the Cubs and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 58% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 61% chance of covering the run line, while the over/under total of 7.5 runs has a 52% chance of going over.

Cubs vs. Astros Odds [6/29/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Astros
Run Line	+1.5 (-196)	-1.5 (+165)
Moneyline	+115	-132
Total	o7.5 (-110)	u7.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Astros Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Astros matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cubs vs. Astros Game-Day Updates and Essential Details

Sunday's MLB matchup between the Astros and Cubs at Daikin Park is scheduled to start at 2:10PM ET.

• Who: Chicago Cubs vs. Houston Astros
• Date: Sunday, June 29, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Daikin Park

Dimers.com's in-depth preview of Sunday's Cubs vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Astros, with a 58% win probability, will likely beat the Cubs on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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