Cubs vs. Astros Prediction: Houston Predicted to Win Friday's MLB Matchup [6/27/2025]

MLB action continues on Friday at 8:10PM ET as the Chicago Cubs lock horns with the Houston Astros at Daikin Park.

Brandon Walter (0-1, 3.80 ERA) will start for the Astros, pitting him against Cade Horton (3-1, 3.73 ERA) for the Cubs.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Astros as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Cubs-Astros game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Astros' chance of winning is 53%, while the Cubs' is 47%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Cubs vs. Astros predictions page.

Astros vs. Cubs Prediction: Who Will Win?

Using innovative machine learning and data, we have simulated the result of Friday's MLB matchup between the Cubs and Astros 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Astros a 53% chance of beating the Cubs.

According to our model, the 8-run over/under has a 52% chance of going over.

Cubs vs. Astros Odds [6/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Astros
Moneyline	+100	-112
Total	o8 (-115)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cubs vs. Astros Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Astros matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cubs vs. Astros Game-Day Updates and Essential Details

Friday's MLB matchup between the Astros and Cubs at Daikin Park is scheduled to commence at 8:10PM ET.

• Who: Chicago Cubs vs. Houston Astros
• Date: Friday, June 27, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's full preview of Friday's Cubs vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Astros, with a 53% win probability, will likely beat the Cubs on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.