Cubs vs. Tigers Prediction: Detroit Predicted to Win Friday's MLB Matchup [6/6/2025]

The Detroit Tigers will take on the Chicago Cubs in MLB action at Comerica Park on Friday, starting at 7:10PM ET.

Tarik Skubal (5-2, 2.26 ERA) will be the starting pitcher for the Tigers, pitting him against Ben Brown (3-3, 5.72 ERA) for the Cubs.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Tigers as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's CHI Cubs-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Tigers' chance of winning is 62%, while the Cubs' is 38%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Cubs vs. Tigers predictions page.

Tigers vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Friday's MLB game between the Cubs and Tigers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Tigers a 62% chance of beating the Cubs.

According to our model, the Cubs (+1.5) have a 59% chance of covering the run line, while the 7-run over/under has an equal 50-50 chance of hitting.

Cubs vs. Tigers Odds [6/6/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Tigers
Run Line	+1.5 (-140)	-1.5 (+120)
Moneyline	+166	-198
Total	o7 (+100)	u7 (-110)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Tigers Picks and Best Bets

Our model's biggest edge in today's Cubs vs. Tigers matchup is on the over/under.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Cubs vs. Tigers Game-Day Updates and Essential Details

Friday's MLB action between the Tigers and Cubs at Comerica Park is scheduled to commence at 7:10PM ET.

• Who: Chicago Cubs vs. Detroit Tigers
• Date: Friday, June 6, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Comerica Park

Dimers.com's comprehensive preview of Friday's Cubs vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 62% win probability, will likely beat the Cubs on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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