Cubs vs. Reds prediction: Why Cincinnati is favored to win Thursday's MLB matchup [9/18/2025]

The Cincinnati Reds will square off with the Chicago Cubs in MLB action at Great American Ball Park on Thursday, beginning at 7:15PM ET.

Hunter Greene (6-4, 3.01 ERA) will start for the Reds, while the Cubs have opted for Colin Rea (10-6, 4.23 ERA).

Based on the latest simulations, Dimers' advanced MLB model projects the Reds as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Cubs vs. Reds predictions page.

Reds vs. Cubs prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Thursday's MLB matchup between the Cubs and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Reds a 56% chance of beating the Cubs.

According to our model, the Cubs (+1.5) have a 62% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of going over.

Cubs vs. Reds odds [9/18/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Reds
Run Line	+1.5 (-166)	-1.5 (+145)
Moneyline	+122	-140
Total	o8.5 (-105)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Cubs vs. Reds picks and best bets

Our model's strongest edge in today's Cubs vs. Reds matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cubs vs. Reds game-day updates and essential details

Thursday's MLB matchup between the Reds and Cubs at Great American Ball Park is scheduled to commence at 7:15PM ET.

• Who: Chicago Cubs vs. Cincinnati Reds
• Date: Thursday, September 18, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Great American Ball Park

Dimers' comprehensive preview of Thursday's Cubs vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Thursday

To make the most of Thursday's mammoth day of sports, headlined by the Dolphins-Bills TNF clash, check out details on the latest Bet365 bonus code "DIMERS" that unlocks $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict the Reds, with a 56% win probability, will likely beat the Cubs on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date probabilities for the World Series, American League, National League and each division.