Cubs vs. Reds prediction: Why Cincinnati is favored to win Sunday's MLB matchup [9/21/2025]

The Cincinnati Reds will face the Chicago Cubs in MLB action at Great American Ball Park on Sunday, beginning at 1:40PM ET.

Andrew Abbott (9-7, 2.88 ERA) will start on the mound for the Reds, up against Jameson Taillon (10-6, 3.93 ERA) for the Cubs.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Reds as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cubs-Reds game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Reds with a win probability of 51%, while the Cubs have 49%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Cubs vs. Reds predictions page.

Reds vs. Cubs prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the outcome of Sunday's MLB game between the Cubs and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Reds a 51% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 66% chance of covering the run line, while the 9-run over/under has a 51% chance of going over.

Cubs vs. Reds odds [9/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Reds
Run Line	+1.5 (-192)	-1.5 (+168)
Moneyline	+106	-110
Total	o9 (+104)	u9 (-121)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Reds picks and best bets

Our model's biggest edge in today's Cubs vs. Reds matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cubs vs. Reds game-day updates and essential details

Sunday's MLB matchup between the Reds and Cubs at Great American Ball Park is scheduled to begin at 1:40PM ET.

• Who: Chicago Cubs vs. Cincinnati Reds
• Date: Sunday, September 21, 2025
• Time: 1:40PM ET/10:40AM PT
• Venue: Great American Ball Park

Dimers' in-depth preview of Sunday's Cubs vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Reds, with a 51% win probability, will likely beat the Cubs on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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