Cubs vs. Reds prediction: Why Cubs are favored to win Saturday's MLB matchup [9/20/2025]

The Cincinnati Reds will face the Chicago Cubs in MLB action at Great American Ball Park on Saturday, beginning at 6:40PM ET.

Zack Littell (9-8, 3.86 ERA) will be on the bump for the Reds, up against Javier Assad (3-1, 4.23 ERA) for the Cubs.

Based on updated simulation results, Dimers' proven MLB model projects the Cubs as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Cubs vs. Reds predictions page.

Reds vs. Cubs prediction: Who will win?

Using innovative machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Cubs and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 51% chance of beating the Reds.

According to our model, the 9-run over/under has a 54% chance of going over.

Cubs vs. Reds odds [9/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Reds
Moneyline	-104	-112
Total	o9 (-108)	u9 (-105)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Reds picks and best bets

Our model's biggest edge in today's Cubs vs. Reds matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Cubs vs. Reds game-day updates and essential details

Saturday's MLB action between the Reds and Cubs at Great American Ball Park is scheduled to start at 6:40PM ET.

• Who: Chicago Cubs vs. Cincinnati Reds
• Date: Saturday, September 20, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers' in-depth preview of Saturday's Cubs vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 51% win probability, will likely beat the Reds on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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