Cubs vs. Reds prediction: Tight battle projected in updated analysis for Friday's MLB matchup [9/19/2025]

The Cincinnati Reds and Chicago Cubs are scheduled to meet in MLB action at Great American Ball Park on Friday, starting at 6:40PM ET.

Nick Lodolo (8-8, 3.30 ERA) will start on the mound for the Reds, up against Shota Imanaga (9-7, 3.29 ERA) for the Cubs.

Based on updated simulation results, Dimers' proven MLB model predicts an equal chance for both the Reds and Cubs to win today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Cubs vs. Reds predictions page.

Reds vs. Cubs prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Friday's MLB game between the Cubs and Reds 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently can't split the two teams, giving both the Cubs and Reds a 50% chance of winning the game.

According to our model, the Reds (+1.5) have a 62% chance of covering the run line, while the 8-run over/under has a 55% chance of going over.

Cubs vs. Reds odds [9/19/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Reds
Run Line	-1.5 (+150)	+1.5 (-176)
Moneyline	-108	-108
Total	o8 (-110)	u8 (+100)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Reds picks and best bets

Our model's biggest edge in today's Cubs vs. Reds matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Cubs vs. Reds game-day updates and essential details

Friday's MLB game between the Reds and Cubs at Great American Ball Park is scheduled to commence at 6:40PM ET.

• Who: Chicago Cubs vs. Cincinnati Reds
• Date: Friday, September 19, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers' comprehensive preview of Friday's Cubs vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict a close game between the Cubs and Reds on Friday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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