Cubs vs. Reds Prediction: Cubs Predicted to Win Saturday's MLB Matchup [5/24/2025]

The Cincinnati Reds will take on the Chicago Cubs in MLB action at Great American Ball Park on Saturday, beginning at 4:10PM ET.

Andrew Abbott (3-0, 1.80 ERA) will be the starting pitcher for the Reds, pitting him against Colin Rea (3-0, 2.38 ERA) for the Cubs.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's CHI Cubs-Cincinnati game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Cubs are more likely to win, while the Reds have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Cubs vs. Reds predictions page.

Reds vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Saturday's MLB game between the Cubs and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 51% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 61% chance of covering the run line, while the over/under total of 9 runs has a 51% chance of staying under.

Cubs vs. Reds Odds [5/24/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Reds
Run Line	-1.5 (+140)	+1.5 (-162)
Moneyline	-110	-105
Total	o9 (-120)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Reds Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Reds matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Cubs vs. Reds Game-Day Updates and Essential Details

Saturday's MLB game between the Reds and Cubs at Great American Ball Park is scheduled to commence at 4:10PM ET.

• Who: Chicago Cubs vs. Cincinnati Reds
• Date: Saturday, May 24, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Great American Ball Park

Dimers.com's full preview of Saturday's Cubs vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any CHI Cubs vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 51% win probability, will likely beat the Reds on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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