Cubs vs. White Sox Prediction: Cubs Predicted to Win Saturday's MLB Matchup [7/26/2025]

The Chicago White Sox will take on the Chicago Cubs in MLB action at Rate Field on Saturday, starting at 7:10PM ET.

Aaron Civale (2-6, 4.76 ERA) will be the starting pitcher for the White Sox, while the Cubs will counter with Cade Horton (3-3, 4.04 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Cubs vs. White Sox predictions page.

White Sox vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Saturday's MLB matchup between the Cubs and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 64% chance of defeating the White Sox.

According to our model, the Cubs (-1.5) have a 51% chance of covering the run line, while the 9-run over/under has an equal 50-50 chance of hitting.

Cubs vs. White Sox Odds [7/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	White Sox
Run Line	-1.5 (-115)	+1.5 (+100)
Moneyline	-188	+158
Total	o9 (-107)	u9 (-110)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Cubs vs. White Sox matchup is on the over/under.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Cubs vs. White Sox Game-Day Updates and Essential Details

Saturday's MLB matchup between the White Sox and Cubs at Rate Field is scheduled to begin at 7:10PM ET.

• Who: Chicago Cubs vs. Chicago White Sox
• Date: Saturday, July 26, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Rate Field

Dimers.com's comprehensive preview of Saturday's Cubs vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 64% win probability, will likely beat the White Sox on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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